Brian Wu

Brian Wu
PhD Candidate

Education

Honors Bachelor of Science with High Distinction in Immunology - University of Toronto, Canada (2013-2017)

Keywords

Pulmonary fibrosis, protein signaling, knee osteoarthritis, autophagy

 

Research Interests

My research interests primarily lie in protein signaling interactions in ephrin-family proteins that contribute to the development of pulmonary fibrosis such as systemic sclerosis-related interstitial lung disease (SSc-related ILD) and idiopathic lung fibrosis (IPF), which are both diseases with poor prognostic outcomes and no medical interventions. I am currently investigating:

  • Ephrin B4 receptor interaction with ephrin B2 ligands in lung fibroblasts and endothelial cells. The protein signalling pathways involved in lung fibrosis are not well known, and I seek to determine key upstream protein interactions and tissue-specific contributions for this process.
  • How genetic ablation of both ephrin B2 and ephrin B4 in either fibroblasts or endothelial cells affect the development of fibrosis in both lung and skin fibrosis mouse models. Identifying key players in fibrosis development can help to identify potential therapeutic targets of disease.
     

My secondary research interest lies in autophagy signalling in knee osteoarthritis development. I am currently working on deciphering the contribution of upstream regulatory protein ULK-1 towards the development of cartilage degeneration in osteoarthritis mouse model.

Recent Accomplishments

Awards

The Arthritis Society PhD Salary Award (2018-2021)

Ontario Graduate Scholarship (2018-2019)

Presentations

2017 Canadian Connective Tissue Society Conference: Oral Presentation