Key Publications

  1. Amanda Ali, Rajiv Gandhi, Pratibha Potla, Sareh Keshavarzi, Osvaldo Espin-Garcia, Konstantin Shestopaloff, Chiara Pastrello, Dylan Bethune-Waddell, Starlee Lively, Anthony Perrucci, Raja Rampersaud, Christian Veillette, Jason Rockel, Igor Jurisica, Tom Appleton, Mohit Kapoor. Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis. Osteoarthritis and Cartilage; accepted July 2020. Science Direct
  2. Jason Rockel, Brian Wu, Sayaka Nakamura, Evgeny Rossomacha, Osvaldo Espin-Garcia, Rajiv Gandhi, Mohit Kapoor. TAT-Beclin-1 induces severe synovial hyperplasia and does not protect from injury-induced osteoarthritis in mice. Osteoarthritis and Cartilage; in press July 2020.  Science Direct
  3. Akihiro Nakamura, Shabana Amanda Ali, Mohit Kapoor. Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks. Bone; June 2020. Science Direct
  4. Mohit Kapoor. Mechanisms of Fibrosis. Seminars in Cell and Developmental Biology. Science Direct
  5. Anusha Ratneswaran, Jason Rockel and Mohit Kapoor. Integration of multi-omics strategy for osteoarthritis phenotyping. Current Opinion in Rheumatology. 2020 Jan;32(1):80-91. doi: 10.1097/BOR.0000000000000680. Pubmed
  6. Nakamura A, Rampersaud YR, Nakamura S, Sharma A, Zeng F, Rossomacha E, Ali SA, Krawetz R, Haroon N, Perruccio AV, Mahomed NN, Gandhi R, Rockel JS, Kapoor M. microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints. Annals of the Rheumatic Diseases. 2018 Oct 4. pii: annrheumdis-2018-213629. doi: 10.1136/annrheumdis-2018-213629. Pubmed | Highlighted in Nature Reviews Rheumatology
     
  7. Endisha H, Rockel J, Jurisica I, Kapoor M. The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets. Journal of Clinical Investigation Insight. 2018 Sep 6;3(17). pii: 121630. doi: 10.1172/jci.insight.121630. Pubmed
     
  8. David Lagares, Parisa Ghassemi-Kakaroodi, Caroline Tremblay, Daniela M. Santos, Paula Grasberger, Neil Ahluwalia, Clemens K. Probst, Sydney B. Montesi, Barry S Shea, Katharine E. Black, Rachel Knipe, Meryem Blati, Murray Baron, Brian Wu, Hassan Fahmi, Rajiv Gandhi, Annie Pardo, Moisés Selman, Jiangping Wu, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Andrew M. Tager and Mohit Kapoor. ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis. Nature Medicine. 2017. 23, 1405–1415.  Pubmed
     
  9. Lietman C*, Wu B*, Lechner S, Shinar A, Sehgal, M, Rossomacha, E, Sharma, A, Gandhi, R, Mohit Kapoor and Pampee Young.(2017). Inhibition of Wnt/β-Catenin signaling ameliorates osteoarthritis in a murine model of experimental OA. Journal of Clinical Investigation Insight; 2018 Feb 8;3(3). pii: 96308. doi: 10.1172/jci.insight.96308.Pubmed
    *equal first author contribution
     
  10. David Lagares, Alba Santos, Paula E. Grasberger, Fei Liu, Clemens K. Probst, Rod A. Rahimi Norihiko Sakai, Tobias Kuehl, Jeremy Ryan, Patrick Bhola, Joan Montero, Mohit Kapoor, Murray Baron, Xaralabos Varelas, Daniel J. Tschumperlin, Anthony Letai, and Andrew M. Tager. Targeted apoptosis of myofibroblasts with the BH3 Mimetic ABT-263 reverses established fibrosis. Science Translational Medicine. Published. 2017, December; 9:420. doi: 10.1126/scitranslmed.aal3765 Pubmed
     
  11. Poulami Datta, Yue Zhang, Alexa Parousis, Anirudh Sharma, Evgeny Rossomacha, Izabela Kacprzak, Brian Wu, Nizar N. Mahomed, Rajiv Gandhi, Jason S. Rockel and Kapoor Mohit. High-fat diet-induced acceleration of osteoarthritis is associated with sustained metabolite signature regulated by Leptin/Autotaxin pathway.  Published. Nature Scientific Reports. 2017 August 15. doi: 10.1038/s41598-017-07963-6. Pubmed
     
  12. Rockel J and Kapoor M. Autophagy: Controlling cell fate in Rheumatic Diseases: Nature Review Rheumatology. 2016. Epub. doi:10.1038/nrrheum.2016.92. PubMed      
     
  13. A. Nakamura, Y. R. Rampersaud, A. Sharma, S.J. Lewis, B. Wu, P. Datta, K. Sundararajan, H. Endisha, E. Rossomacha, J. Rockel, I. Jurisica, and M. Kapoor. (2016). Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration. Journal of Clinical Investigation Insight. 2016(1): 12. PubMed
     
  14. Ying‐Hua Li, Ghazaleh Tavallaee, Tomas Tokar, Akihiro  Nakamura, Kala Sundararajan, Amanda Weston, Anirudh Sharma, Nizar N. Mahomed, Rajiv Gandhi, Igor Jurisica and Kapoor M. Identification of synovial fluid microRNA signature in knee OA: Differentiating early‐and late‐stage knee osteoarthritis. Osteoarthritis and Cartilage. 2016 April 30. pii: S1063‐ 4584(16)30057‐7 doi: 10.1016/j.joca.2016.04.019  PMID: 27143365. PubMed
     
  15. Vasheghani F, Zhang Y, Yinghua Li, Meryem Blati, Hassan Fahmi, Bertrand Lussier, Peter Roughley, David Lagares, Daniel Lajeunesse, K. Wayne Marshall, Raja Rampersaud, Nizar N. Mahomed, Rajiv Gandhi, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Kapoor M. PPARgamma deficiency results in severe accelerated Osteoarthritis associated with defective mTOR and autophagy signalling. Annals of The Rheumatic Diseases. 2015 Mar. 74(3):569-78. PMID: 25573665 PubMed
     
  16. Yuen YH, Lagares D, Tager AM and Kapoor M. Fibrosis- A lethal component of rheumatic diseases. Nature Reviews Rheumatology: 2014 Jul;10(7):390- 402. doi: 10.1038/nrrheum.2014.53 PMID: 24752182. PubMed
     
  17. Zhang Y, Vasheghani F, Li YH, Blati M, Simeone K, Fahmi H, Lussier B, Roughley P, Lagares D, Pelletier JP, Martel-Pelletier J, Kapoor M. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from Osteoarthritis. Annals of the Rheumatic Diseases. 2015 Jul;74(7):1432-40 doi: 10.1136/annrheumdis-204599. PMID: 24651621. PubMed
     
  18. Vasheghani F , Monemdjou R , Fahmi H , Zhang Y , Perez G , Blati M , St-Arnaud R , Pelletier JP , Beier
F , Martel-Pelletier J , Kapoor M. (2013). Adult Cartilage-Specific Peroxisome Proliferator-Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype. The American Journal of Pathology. 182(4): 1099-1106. PubMed
     
  19. Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M. (2012). Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. Arthritis and Rheumatism. 64(5): 1551-1561. PubMed
     
  20. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. (2011). Role of Proinflammatory Cytokines in the Pathophysiology of Osteoarthritis. Nature Reviews Rheumatology. 7(1): 33-42. PubMed
     
  21. Book: Editors: Kapoor M and Mahomed N.N. (2015). Osteoarthritis: Pathogenesis, diagnosis, available treatments, drug safety, Regenerative and Personalized Medicine. Kapoor M and Nizar Mahomed. Publisher: ADIS. Springer