Key Publications

  1. Nakamura A, Rampersaud YR, Nakamura S, Sharma A, Zeng F, Rossomacha E, Ali SA, Krawetz R, Haroon N, Perruccio AV, Mahomed NN, Gandhi R, Rockel JS, Kapoor M. microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints. Annals of the Rheumatic Diseases. 2018 Oct 4. pii: annrheumdis-2018-213629. doi: 10.1136/annrheumdis-2018-213629. Pubmed
     
  2. Endisha H, Rockel J, Jurisica I, Kapoor M. The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets. Journal of Clinical Investigation Insight. 2018 Sep 6;3(17). pii: 121630. doi: 10.1172/jci.insight.121630. Pubmed
     
  3. David Lagares*, Parisa Ghassemi-Kakaroodi*, Caroline Tremblay, Daniela M. Santos, Paula Grasberger, Neil Ahluwalia, Clemens K. Probst, Sydney B. Montesi, Barry S Shea, Katharine E. Black, Rachel Knipe, Meryem Blati, Murray Baron, Brian Wu, Hassan Fahmi, Rajiv Gandhi, Annie Pardo, Moisés Selman, Jiangping Wu, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Andrew M. Tager and Mohit Kapoor. ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis. Nature Medicine. 2017. 23, 1405–1415.  Pubmed
    *equal first author contribution
     
  4. Lietman C*, Wu B*, Lechner S, Shinar A, Sehgal, M, Rossomacha, E, Sharma, A, Gandhi, R, Mohit Kapoor and Pampee Young.(2017). Inhibition of Wnt/β-Catenin signaling ameliorates osteoarthritis in a murine model of experimental OA. Journal of Clinical Investigation Insight; 2018 Feb 8;3(3). pii: 96308. doi: 10.1172/jci.insight.96308.Pubmed
    *equal first author contribution
     
  5. David Lagares, Alba Santos, Paula E. Grasberger, Fei Liu, Clemens K. Probst, Rod A. Rahimi Norihiko Sakai, Tobias Kuehl, Jeremy Ryan, Patrick Bhola, Joan Montero, Mohit Kapoor, Murray Baron, Xaralabos Varelas, Daniel J. Tschumperlin, Anthony Letai, and Andrew M. Tager. Targeted apoptosis of myofibroblasts with the BH3 Mimetic ABT-263 reverses established fibrosis. Science Translational Medicine. Published. 2017, December; 9:420. doi: 10.1126/scitranslmed.aal3765 Pubmed
     
  6. Poulami Datta, Yue Zhang, Alexa Parousis, Anirudh Sharma, Evgeny Rossomacha, Izabela Kacprzak, Brian Wu, Nizar N. Mahomed, Rajiv Gandhi, Jason S. Rockel and Kapoor Mohit. High-fat diet-induced acceleration of osteoarthritis is associated with sustained metabolite signature regulated by Leptin/Autotaxin pathway.  Published. Nature Scientific Reports. 2017 August 15. doi: 10.1038/s41598-017-07963-6. Pubmed
     
  7. Rockel J and Kapoor M. Autophagy: Controlling cell fate in Rheumatic Diseases: Nature Review Rheumatology. 2016. Epub. doi:10.1038/nrrheum.2016.92. PubMed      
     
  8. A. Nakamura, Y. R. Rampersaud, A. Sharma, S.J. Lewis, B. Wu, P. Datta, K. Sundararajan, H. Endisha, E. Rossomacha, J. Rockel, I. Jurisica, and M. Kapoor. (2016). Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration. Journal of Clinical Investigation Insight. 2016(1): 12. PubMed
     
  9. Ying‐Hua Li, Ghazaleh Tavallaee, Tomas Tokar, Akihiro  Nakamura, Kala Sundararajan, Amanda Weston, Anirudh Sharma, Nizar N. Mahomed, Rajiv Gandhi, Igor Jurisica and Kapoor M. Identification of synovial fluid microRNA signature in knee OA: Differentiating early‐and late‐stage knee osteoarthritis. Osteoarthritis and Cartilage. 2016 April 30. pii: S1063‐ 4584(16)30057‐7 doi: 10.1016/j.joca.2016.04.019  PMID: 27143365. PubMed
     
  10. Vasheghani F, Zhang Y, Yinghua Li, Meryem Blati, Hassan Fahmi, Bertrand Lussier, Peter Roughley, David Lagares, Daniel Lajeunesse, K. Wayne Marshall, Raja Rampersaud, Nizar N. Mahomed, Rajiv Gandhi, Jean-Pierre Pelletier, Johanne Martel-Pelletier and Kapoor M. PPARgamma deficiency results in severe accelerated Osteoarthritis associated with defective mTOR and autophagy signalling. Annals of The Rheumatic Diseases. 2015 Mar. 74(3):569-78. PMID: 25573665 PubMed
     
  11. Yuen YH, Lagares D, Tager AM and Kapoor M. Fibrosis- A lethal component of rheumatic diseases. Nature Reviews Rheumatology: 2014 Jul;10(7):390- 402. doi: 10.1038/nrrheum.2014.53 PMID: 24752182. PubMed
     
  12. Zhang Y, Vasheghani F, Li YH, Blati M, Simeone K, Fahmi H, Lussier B, Roughley P, Lagares D, Pelletier JP, Martel-Pelletier J, Kapoor M. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from Osteoarthritis. Annals of the Rheumatic Diseases. 2015 Jul;74(7):1432-40 doi: 10.1136/annrheumdis-204599. PMID: 24651621. PubMed
     
  13. Vasheghani F , Monemdjou R , Fahmi H , Zhang Y , Perez G , Blati M , St-Arnaud R , Pelletier JP , Beier
F , Martel-Pelletier J , Kapoor M. (2013). Adult Cartilage-Specific Peroxisome Proliferator-Activated Receptor Gamma Knockout Mice Exhibit the Spontaneous Osteoarthritis Phenotype. The American Journal of Pathology. 182(4): 1099-1106. PubMed
     
  14. Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M. (2012). Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. Arthritis and Rheumatism. 64(5): 1551-1561. PubMed
     
  15. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. (2011). Role of Proinflammatory Cytokines in the Pathophysiology of Osteoarthritis. Nature Reviews Rheumatology. 7(1): 33-42. PubMed
     
  16. Book: Editors: Kapoor M and Mahomed N.N. (2015). Osteoarthritis: Pathogenesis, diagnosis, available treatments, drug safety, Regenerative and Personalized Medicine. Kapoor M and Nizar Mahomed. Publisher: ADIS. Springer